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T of eIF2a sequences (Figure 1, light blue background). While the multiple sequenceRothenburg et al. BMC Microbiology 2011, 11:56 http://www.biomedcentral.com/1471-2180/11/Page 3 ofRCVZ vIF2a REI vIF2a ATV vIF2a BIV vIF2a TFV vIF2a EHNV vIF2a IMR vIF2a FV3 vIF2a SGRV vIF2a VACV K3L Sc eIF2a Ac eIF2a Ce eIF2a Bm eIF2a Hm eIF2a Sp eIF2a Xt eIF2a Dr eIF2a Hs eIF2a* MAHNRFYSEILPRQGDVTMCRVLPHSDSWGEGVYV
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T of eIF2a sequences (Figure 1, light blue background). While the multiple sequenceRothenburg et al. BMC Microbiology 2011, 11:56 http://www.biomedcentral.com/1471-2180/11/Page 3 ofRCVZ vIF2a REI vIF2a ATV vIF2a BIV vIF2a TFV vIF2a EHNV vIF2a IMR vIF2a FV3 vIF2a SGRV vIF2a VACV K3L Sc eIF2a Ac eIF2a Ce eIF2a Bm eIF2a Hm eIF2a Sp eIF2a Xt eIF2a Dr eIF2a Hs eIF2a* MAHNRFYSEILPRQGDVTMCRVLPHSDSWGEGVYV
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The fish lineage probably led to the emergence of PKR and PKZ in a fish ancestor, and might have helped to extend the spectrum of viralnucleic acids that can be recognized [27]. Although higher vertebrates lack PKZ genes, they contain a different Za-containing protein, termed ZBP1, which binds Z-DNA and has been implicated in the recognition of viral DNA and the induction of an antiviral response
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