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Of STING reduces the overproduction of IFN and chronic inflammation [90]. Supporting this idea, gain-of-function mutations in TMEM173, gene encoding STING, were recently reported in subjects with a monogenic condition characterized by high IFN levels and vascular and pulmonary inflammation [91, 92]. Loss-of-function polymorphisms for STING are also known, however they have not yet been linked to a
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Pool Remodeling - Pool tile seems to add just the right touch in and around a pool. It is very versatile and can be used as coping or within the actual...
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Riggering exocytosis, directly killing cells, or indirectly damaging Weibel alade bodies. Our cytotoxicity data above suggest that antibody to HLA class I does not kill endothelial cells directly (Figs. 1 D and E). To further show that antibody triggers regulated secretion of VWF from endothelialYamakuchi et al.Fig. 3. Effects of both C5a and antibody to HLA upon exocytosis. (A) C5a added to anti-
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