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The current examine confirmed the WT1 gene was alternatively spliced at Ex4a to supply isoforms with opposing roles in apoptosis, anti-apoptotic isoforms (big WT1 isoforms) and pro-apoptotic isoform (truncated Ex4a(+)WT1 isoform). Quite a few other genes included in apoptosis, these kinds of as p53 [39], Survivin [40], Fas [41], and caspase-9 [42] are identified to produce isoforms with opposing r