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This paper were supported by the Flow Cytometry Core Facility of The Cancer Institute of New Jersey (P30CA072720). We would like to express our gratitude to Dr. P. Leif Bergsagel for his critical comments and stimulating discussions on this manuscript, and for providing us the human MM cell lines used in this study. We would also like to thank Anand Desai, Jacqueline Baron, Benjamin Kreider, Will
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This paper were supported by the Flow Cytometry Core Facility of The Cancer Institute of New Jersey (P30CA072720). We would like to express our gratitude to Dr. P. Leif Bergsagel for his critical comments and stimulating discussions on this manuscript, and for providing us the human MM cell lines used in this study. We would also like to thank Anand Desai, Jacqueline Baron, Benjamin Kreider, Will
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To DMT superfamily member RarD (Figure 5B) resulted in higher sequence similarity values (data not shown). As observed for SMR-BAT alignments (Figure 5A), the SMR fusion 'N-terminus regions' (TM1? and TM5?) showed the poorest TM domain alignments to Nterminus and central regions of DMT (TM1? and TM5?6) and MFS (TM1? and TM6?) sequences. It is important to note that the lack of TM domain alignabili
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This paper were supported by the Flow Cytometry Core Facility of The Cancer Institute of New Jersey (P30CA072720). We would like to express our gratitude to Dr. P. Leif Bergsagel for his critical comments and stimulating discussions on this manuscript, and for providing us the human MM cell lines used in this study. We would also like to thank Anand Desai, Jacqueline Baron, Benjamin Kreider, Will
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This paper were supported by the Flow Cytometry Core Facility of The Cancer Institute of New Jersey (P30CA072720). We would like to express our gratitude to Dr. P. Leif Bergsagel for his critical comments and stimulating discussions on this manuscript, and for providing us the human MM cell lines used in this study. We would also like to thank Anand Desai, Jacqueline Baron, Benjamin Kreider, Will
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Imulates and TGFBR inhibition represses EGR2 mRNA expression in both HMECs as well as MMECs (Additional file 2: Figure S2, Fig. 2). We have also observed that tumors derived from Sfrp1-/- mice express significantly higher levels of both Tgfb1 and Egr2 mRNA (data not shown). Dillon et al. revealed that Egr2 expression is upregulated in Erbb2 driven mammary tumors [25]. However, these researchers di
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MRNA expression of CD163 (left panal) and M1 polarization was evaluated by HLA-DRA mRNA expression (right panal). b Explant mammary gland sections were subjected to immunohistochemical analysis, stained for CD163 (left panel) or HLA-DRA (right panel) and images were captured at 100X. Representative pictures are displayed for tissues from each treatment group which was performed in triplicate sampl
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MRNA expression of CD163 (left panal) and M1 polarization was evaluated by HLA-DRA mRNA expression (right panal). b Explant mammary gland sections were subjected to immunohistochemical analysis, stained for CD163 (left panel) or HLA-DRA (right panel) and images were captured at 100X. Representative pictures are displayed for tissues from each treatment group which was performed in triplicate sampl
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MRNA expression of CD163 (left panal) and M1 polarization was evaluated by HLA-DRA mRNA expression (right panal). b Explant mammary gland sections were subjected to immunohistochemical analysis, stained for CD163 (left panel) or HLA-DRA (right panel) and images were captured at 100X. Representative pictures are displayed for tissues from each treatment group which was performed in triplicate sampl